Dr. Gerdemann’s research lab is a young, dynamic and innovative laboratory embedded within the larger CTSI research community at Boston Children’s Hospital, focusing on the mechanisms of cancer-directed T cell therapeutics, including chimeric antigen receptor (CAR) engineered T cells.

Our research employs a diverse range of in vivo and in vitro models, including state-of-the-art non-human primate models of transplantation and CAR T cell therapy, patient-derived samples, and xenogeneic human-to-mouse cancer models to perform detailed mechanistic studies. This work has led to the identification of novel immune pathologies in CAR T cell therapy.

We are seeking a highly motivated candidate to join our cellular therapy research team to advance CAR T cell therapeutics with the goal of translating key findings into clinical applications for pediatric oncology. The candidate will work with non-human primate and human cells, as well as xenogeneic models, generating impactful data to improve CAR T cell therapies.

In addition to research responsibilities, the candidate will also serve as the lab manager, overseeing lab organization, inventory management, and ordering supplies, ensuring efficient daily operations. This role provides an excellent opportunity to develop higher-level management and organizational skills while contributing to innovative CAR T cell research.

Key Responsibilities

• Process blood and tissue biopsy samples from human and non-human primates
• Perform multicolor flow cytometry and cell sorting
• Conduct in vitro T cell immune assays and CAR T cell generation/evaluation
• Perform cloning, molecular biology, and CRISPR/Cas9 gene editing techniques
• Construct bulk and single-cell cDNA libraries for Next-Gen sequencing
• Lab management duties, including inventory control, reagent supply maintenance, and ordering

Minimum Requirements
Education

• Bachelor’s degree in biology, biochemistry, chemistry, or a related field

Experience

• One year of relevant Research Experience
• Strong organizational skills, attention to detail, and a solid work ethic
• Ability to quickly learn new techniques and work collaboratively in a team-oriented environment

Preferred Experience:

• Background in immunology, molecular biology, biochemistry, or cell biology
• Experience in sample processing, flow cytometry, cell sorting, or molecular biology techniques
• Knowledge of CRISPR/Cas9-based gene editing
• Familiarity with lab safety protocols and handling of hazardous materials
• Experience working with animal/mouse models is a plus
• Strong problem-solving skills and adaptability to work flexible hours as needed

Why Join Us?
This position offers an opportunity to work in a high-impact, collaborative, and engaging research environment, where you will gain hands-on training in cutting-edge immunological techniques. You will be part of a team dedicated to making a direct impact on pediatric cancer treatment through innovative CAR T cell research.